![]() The relationship of time of day, sleep and other factors to the incidence of epileptic seizures. Landmark study in the Lingfield epilepsy colony that confirmed circadian peak seizure times and described multidien cycles of seizures with patient-specific periodicity. Epilepsy: its symptoms, treatment, and relation to other chronic convulsive diseases. Landmark study in the Lingfield epilepsy colony that revealed circadian peak seizure times in nocturnal and diurnal epilepsies. Time of day in relation to convulsions in epilepsy. Epilepsy and other chronic convulsive diseases: their causes, symptoms, & treatment. De l’étiologie de l’épilepsie: et des indications que l’étude des causes peut fournir pour le traitement de cette maladie 94 (Bailliere, 1854). Tome Douzième Contenant le Traité de l’epilepsie (Chez Francois Grasset & Comp., 1784).Įcheverria, M. Œuvres de Monsieur Tissot, Nouvelle Édition. A treatise concerning the influence of the sun and moon upon human bodies, and the diseases thereby produced 36–47 (J. The falling sickness: a history of epilepsy from the Greeks to the beginnings of modern neurology (The Johns Hopkins University Press, 1994). Landmark historical study that revealed periodicity in seizure diaries kept by patients. The periodic features of some seizure states. Translation and analysis of a cuneiform text forming part of a Babylonian treatise on epilepsy. In essence, this Review addresses the broad question of why seizures occur when they occur. ![]() The potential clinical applications of a knowledge of cycles in epilepsy, including seizure forecasting and chronotherapy, are discussed in the context of the emerging concept of seizure risk. We discuss advances in our understanding of the mechanistic underpinnings of these cycles and highlight the knowledge gaps that remain. Here, we review this evidence, synthesizing data from historical observational studies, modern implanted devices, electronic seizure diaries and laboratory-based animal neurophysiology. Chronic recordings of brain activity in humans and in animals have yielded converging evidence for the existence of cycles of epileptic brain activity that operate over diverse timescales: daily (circadian), multi-day (multidien) and yearly (circannual). ![]() Observations that seizures are cyclical date back to antiquity, but recent technological advances have, for the first time, enabled cycles of seizure occurrence to be quantitatively characterized with direct brain recordings. A canonical view holds that seizures, the characteristic sign of epilepsy, occur at random, but, for centuries, humans have looked for patterns of temporal organization in seizure occurrence. LTG and GBP improve sleep stability while reducing seizures.Epilepsy is among the most dynamic disorders in neurology. We conclude that CBZ-CR disrupts REM sleep, but only during acute administration. ![]() GBP increased REM sleep percentage, increased mean duration of REM periods, reduced number of awakenings, and reduced stage 1 sleep percentage. LTG increased REM sleep, reduced number of entries into REM sleep, decreased number of phase shifts, and decreased percentage of slow-wave sleep. In the TLE group, these effects were almost completely reversed after chronic treatment. The acute administration of CBZ-CR increased number of stage shifts, reduced REM sleep, and increased REM sleep fragmentation. Significant findings are as follows for each study. Results were compared with those of nine healthy volunteers LTG: at baseline, after 3 months of stable treatment with LTG (300 mg/day) GBP: at baseline, after 3 months of stable treatment with GBP (1800 mg/day). ![]() PSG was performed in all three studies as follows: CBZ-CR: at baseline, after initial administration of CBZ-CR 400 mg, and after 1 month of CBZ-CR treatment (400 mg BID) in a sample of seven temporal lobe epileptic (TLE) patients. Despite widespread clinical use, their effects on sleep are not well known. Antiepileptic drugs (AEDs) control seizures and also modify hypnic structure. Our objective was to determine, in three separate studies, the effects of controlled-release carbamazepine (CBZ-CR), lamotrigine (LTG), and gabapentin (GBP) on nocturnal sleep in epilepsy. ![]()
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